The Rabbit Anti-Histone H3.3 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to H3-3A, H3-3B, H3.3 histone A, and H3.3 histone B. This antibody recognizes Human antigen. The Rabbit Anti-Histone H3.3 Antibody has been validated for the following applications: EIA, Immunoassay, and ELISA.
Description
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling